The lease on my 2011 E350 is up this month so I took it out for one last road trip! 5 days, more than 1800 miles and a little bit of mud later we are back in Georgia. The E350 averaged nearly 26 mpg in mixed driving – about 1500 highway and another 300 in town. I am still impressed with the comfort, handling and good looks of this vehicle. I might miss it a little when I turn it in!